胡学达
BTH-BIOPIC副主任
个人履历
2021.1-至今 北京百奥智汇有限公司 副总裁/副研究员
2017.9-2020.12，北京大学，北京大学生物医学前沿创新中心，助理研究员
2012.4-2017.8，中国医学科学院肿瘤医院/肿瘤研究所，助理研究员
2006.9-2012.3，中国科学院北京基因组研究所，基因组学，博士
主要研究方向
获奖及荣誉
2021，北京市自然科学一等奖
2023，一种以非疾病诊断或治疗为目的的非小细胞肺癌 PD-1 免疫治疗响应预测方法（202310326560.5），发明专利，实审阶段
代表性论文及论著
1. Gui Y#, Guo G#, Huang Y#, Hu X#, Tang A, Gao S, Wu R, Chen C, Li X, Zhou L, He M, Li Z, Sun X, Jia W, Chen J, Yang S, Zhou F, Zhao X, Wan S, Ye R, Liang C, Liu Z, Huang P, Liu C, Jiang H, Wang Y, Zheng H, Sun L, Liu X, Jiang Z, Feng D, Chen J, Wu S, Zou J, Zhang Z, Yang R, Zhao J, Xu C, Yin W, Guan Z, Ye J, Zhang H, Li J, Kristiansen K, Nickerson ML, Theodorescu D, Li Y, Zhang X, Li S, Wang J, Yang H, Wang J, Cai Z. Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet. 2011, 7;43(9):875-8.
2. Guo G#, Gui Y#, Gao S#, Tang A#, Hu X#, Huang Y, Jia W, Li Z, He M, Sun L, Song P, Sun X, Zhao X, Yang S, Liang C, Wan S, Zhou F, Chen C, Zhu J, Li X, Jian M, Zhou L, Ye R, Huang P, Chen J, Jiang T, Liu X, Wang Y, Zou J, Jiang Z, Wu R, Wu S, Fan F, Zhang Z, Liu L, Yang R, Liu X, Wu H, Yin W, Zhao X, Liu Y, Peng H, Jiang B, Feng Q, Li C, Xie J, Lu J, Kristiansen K, Li Y, Zhang X, Li S, Wang J, Yang H, Cai Z, Wang J. Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet. 2011, 4;44(1):17-9.
3. Hu X, Zhang Z. Understanding the Genetic Mechanisms of Cancer Drug Resistance Using Genomic Approaches. Trends Genet. 2016, 32(2):127-37.
4. Tang Z, Li C, Zhang K, Yang M, Hu X. GE-mini: a mobile APP for large-scale gene expression visualization. Bioinformatics. 2017, 33(6):941-943.
5. Zhang F, Bai H, Gao R, Fei K, Duan J, Zhang Z, Wang J, Hu X. Dynamics of peripheral T cell clones during PD-1 blockade in non-small cell lung cancer. Cancer Immunol Immunother. 2020, 69(12):2599-2611.
6. Rao M, Wang X, Guo G, Wang L, Chen S, Yin P, Chen K, Chen L, Zhang Z, Chen X, Hu X*, Hu S*, Song J*. Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level. Basic Res Cardiol. 2021, 116(1):55.
7. Zhang Y#, Chen H#, Mo H#, Hu X#, Gao R, Zhao Y, Liu B, Niu L, Sun X, Yu X, Wang Y, Chang Q, Gong T, Guan X, Hu T, Qian T, Xu B, Ma F, Zhang Z, Liu Z. Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer. Cancer Cell. 2021, 5:S1535-6108(21)00499-2.
8. Zheng L, Qin S, Si W, Wang A, Xing B, Gao R, Ren X, Wang L, Wu X, Zhang J, Wu N, Zhang N, Zheng H, Ouyang H, Chen K, Bu Z*, Hu X*, Ji J*, Zhang Z*. Pan-cancer single-cell landscape of tumor-infiltrating T cells. Science. 2021, 374(6574):abe6474.
9. Liu B#, Hu X#, Feng K#, Gao R, Xue Z, Zhang S, Zhang Y, Corse E, Hu Y, Han W, Zhang Z. Temporal single cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer. Nat Cancer. 2022, 3(1):108-121.
10. Jing Nie#*, Chunmeng Wang#, Liangtao Zheng#, Yang Liu, Chengcheng Wang, Yixin Chang, Yudi Hu, Bing Guo, Yuting Pan, Qingming Yang, Xueda Hu*, Weidong Han*. Epigenetic agents plus anti-PD-1 reprogram the tumor microenvironment and restore antitumor efficacy in Hodgkin lymphoma. Blood. 2024, 144(18):1936-1950.
11. 胡学达，杨焕明，赫捷，吕有勇. 肿瘤基因组学与全球肿瘤基因组计划. 科学通报. 2015, 60 (09).